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Clonazepam 1 mg vs valium 10mg 5.9 (1,874) 5.6 (1,726) 4.3 (1,682) 4.5 (1,664) (1,622) 4.4 (1,597) (1,588) 0.0012 b c d 5-HT (milligrams) n (%) mg/dL 50.9 (11.8) (11.7) 52.7 (12.0) 53.2 (12.1) 53.7 (11.7) 53.4 (12.8) 0.0031 The incidence of acute adverse events and post-administration discontinuations (PDs) at 12-weeks ranged between 2.5% and 16%. No patients were discontinued by either FDA-licensed or alternative medicine (AMA)-tolerated means. Acute adverse events included headache and irritability at a rate of 4.7%. In the randomized crossover study, patients completed daily dosing, with two drug groups of 10 patients assigned to the 1 mg, 10 15 and 20 mg dose, respectively. Patients randomized to valium 10 mg did not see an overall incidence of PED's at week 12 compared with all other groups. No serious adverse events were reported. No deaths or hospitalizations were observed. Conclusions: Valium does not cause clinically important changes post dose on plasma levels of 5-HT, nor does the drug alter efficacy of any other psychotropic treatments. It had minimal, clinically not significant, or moderate adverse effects. Author Conclusion: Valium does not change 5-HT plasma levels, but the drug can alleviate its adverse effects without decreasing efficacy. Federico et al. Review Article Nexium 1 mg vs clonazepam valium 10 3.6 (1,844) 3.2 (1,619) 3.4 (1,531) (1,478) 3.5 (1,469) 3.7 (1,437) 3.6 (1,425) 0.0018 b c e 1 0 mg 0 1 1 mg 20 10 5 1 b d 0 1 20 mg 5 40 25 0 1 0 mg 10 5 40 25 Dosing frequency on a daily basis does not influence 5-HT plasma levels in healthy volunteers (n=40) who take Nexium 1 mg Nexium is no more potent than both clonazepam and valium for reducing symptoms of anxiety and/or agitation in an open-label, dose-finding study, but it is superior to valium and has a faster onset of action than valium. No differences in efficacy or tolerability were noted at 6-weeks as a result of the study. Author Conclusion: Nexium is as effective clonazepam an anxiolytic and should be considered with clonazepam, valium, and atypical antipsychotics in appropriate cases. Pertanib 1 mg vs. Valium 10 3.7 (1,822) 2.2 (1,610) 2.4 (1,512) 1.8 (1,450) 7.0 (1,411) 4.7 (1,397) 3.1 (1,371) -0.0112 b c e Valium 1 mg vs. pertanib (the exact dose) Nexium in the treatment of moderate-to-severe anxiety disorder: 1 mg daily Conclusions: Valium is effective for some people as an anxiolytic and to prevent the development of tolerance. A placebo-controlled, double-blind study of 10 healthy volunteers showed that patients taking valium in 10 different daily doses showed a reduction in clinical symptoms of moderate-to-severe anxiety in response to 1 mg daily of the drug. No dose-related differences occurred in efficacy or tolerability of valium daily dosing compared with pertanib. Author Conclusion: Valium is effective as an anxiolytic to prevent the development of tolerance and some patients can tolerate doses higher than the established standard (10 mg, equivalent to 200 mg clonazep)

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